PT-141

For Research Use Only | Not for Human or Veterinary Use

Description:
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide melanocortin receptor agonist derived from the metabolite of Melanotan II. In preclinical laboratory research, PT-141 is investigated for its selective activity at melanocortin receptors MC3R and MC4R, distinguishing it from broader melanocortin agonists. The peptide’s cyclic lactam structure and C-terminal free acid (rather than amide) differentiate it structurally from its parent compound Melanotan II. PT-141 serves as a key pharmacological tool for studying melanocortin receptor-mediated central nervous system pathways, particularly those involved in sexual function, arousal signaling, and hypothalamic neuroendocrine regulation.

Scientific Specifications:

• Peptide Name: PT-141 (Bremelanotide)
• Type: Synthetic Cyclic Heptapeptide (Melanocortin Receptor Agonist)
• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
• Molecular Formula: C₅₀H₆₈N₁₄O₁₀
• Molecular Weight: 1025.18 g/mol
• CAS Number: 189691-06-3
• PubChem CID:9941379
• Form: Lyophilized powder
• Storage: Store dry in a cool, dark environment (2°C to 8°C)

Research Context:
PT-141 is commonly studied for its potential effects on:

• MC3R and MC4R selective agonism and melanocortin receptor binding pharmacology
• Central nervous system-mediated sexual function and arousal signaling pathways
• Hypothalamic melanocortin circuit activation and neuroendocrine downstream effects
• Structure-activity relationships between cyclic melanocortin peptide analogues
• Comparative pharmacology with non-selective melanocortin agonists (e.g., Melanotan II)
• Dopaminergic pathway interactions and reward-related neural circuit modulation

Intended Use:
This product is intended strictly for laboratory research applications only by qualified scientific personnel. It is not approved for human or animal consumption, and may not be used in foods, drugs, supplements, cosmetics, or diagnostics.

Legal Disclaimer:
The statements provided and this compound have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of any disease. Use is restricted to qualified researchers operating in certified laboratory environments.

Terms of Sale:
By purchasing this product, the buyer affirms they are a qualified researcher or institutional purchaser, fully responsible for proper handling, storage, and legal compliance.