GHK-CU

GHK-Cu – Premium Research Peptide

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide first isolated from plasma samples in 1973. The peptide consists of three amino acids (Gly-His-Lys) complexed with copper(II) ions through high-affinity chelation. This coordination stabilizes copper in a redox-controlled form suitable for experimental systems. Endogenous GHK-Cu concentrations have been shown to vary across biological samples, making it a compound of significant interest in gene expression and metalloprotein research.

This product is intended for laboratory and research purposes only. Research Use Only.

Research Applications

GHK-Cu has been extensively studied in peer-reviewed literature for its role in multiple biological processes. The peptide provides researchers with a tool for investigating:

• Copper homeostasis and metalloprotein regulation
• Extracellular matrix synthesis and remodeling
• Matrix protein and glycosaminoglycan expression in fibroblast models
• Gene expression modulation (studies indicate GHK-Cu may influence over 4,000 genes at the transcriptional level)
• Antioxidant enzyme regulation and redox signaling
• Cellular stress response and matrix turnover mechanisms

Published research demonstrates that GHK-Cu interacts with extracellular matrix components, transcriptional regulators, and membrane-associated proteins. Studies suggest the peptide may stimulate both the synthesis and regulated breakdown of structural matrix proteins, including metalloproteinases and their inhibitors.

Technical Specifications

• Sequence: Gly-His-Lys·Cu²⁺
• CAS Number: 89030-95-5
• Molecular Formula: C₁₄H₂₃CuN₆O₄
• Molecular Weight: 403.92 g/mol
• PubChem CID: 73587
• Purity: ?99%
• Form: Lyophilized powder
• Storage: Store at -20°C, protected from light