SS-31

Description:

SS-31 (Elamipretide, MTP-131) is a synthetic mitochondria-targeted tetrapeptide that selectively binds to cardiolipin, a phospholipid uniquely concentrated in the inner mitochondrial membrane. In preclinical laboratory research, SS-31 is investigated for its ability to penetrate cell membranes and concentrate at the mitochondrial inner membrane, where it stabilizes cardiolipin-cytochrome c interactions and optimizes electron transport chain function. The peptide’s alternating aromatic-cationic motif (D-Arg-Dmt-Lys-Phe, where Dmt = 2′,6′-dimethyltyrosine) enables cell-permeable, mitochondria-selective accumulation independent of mitochondrial membrane potential, making it a key research tool in mitochondrial medicine, bioenergetics, and oxidative stress biology.

Scientific Specifications:

Peptide Name: SS-31 (Elamipretide / MTP-131)

Type: Synthetic Mitochondria-Targeted Tetrapeptide

Sequence: D-Arg-Dmt-Lys-Phe-NH₂ (Dmt = 2′,6′-dimethyltyrosine)

Molecular Formula: C₃₂H₄₉N₉O₅

Molecular Weight: 639.79 g/mol

CAS Number: 736992-21-5

PubChem CID: 11764719

Form: Lyophilized powder

Storage: Store dry in a cool, dark environment (2°C to 8°C)

Research Context:

SS-31 is commonly studied for its potential effects on:

Cardiolipin stabilization and cytochrome c electron transfer optimization

Mitochondrial electron transport chain efficiency and ATP production enhancement

Reactive oxygen species (ROS) generation reduction at complex I and III

Mitochondrial membrane potential preservation under ischemia-reperfusion conditions

Age-related mitochondrial dysfunction and cellular bioenergetic decline models

Cardiolipin peroxidation prevention and mitochondrial cristae structural integrity

Intended Use:

This product is intended strictly for laboratory research applications only by qualified scientific personnel. It is not approved for human or animal consumption, and may not be used in foods, drugs, supplements, cosmetics, or diagnostics.

Legal Disclaimer:

The statements provided and this compound have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of any disease. Use is restricted to qualified researchers operating in certified laboratory environments.

Terms of Sale:

By purchasing this product, the buyer affirms they are a qualified researcher or institutional purchaser, fully responsible for proper handling, storage, and legal compliance.