Melanotan II

Description:
Melanotan II (MT-II) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH), originally developed at the University of Arizona. In preclinical laboratory research, Melanotan II has been extensively investigated for its activity at melanocortin receptors (MC1R through MC5R), with particular affinity for MC1R, MC3R, MC4R, and MC5R. The compound’s cyclic lactam structure confers enhanced metabolic stability compared to the linear endogenous ligand, making it a widely used pharmacological tool in melanocortin signaling research, pigmentation biology, and studies of energy homeostasis and sexual function pathways.

Scientific Specifications:

• Peptide Name: Melanotan II (MT-II)
• Type: Synthetic Cyclic Heptapeptide (α-MSH Analogue)
• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
• Molecular Formula: C₅₀H₆₉N₁₅O₉
• Molecular Weight: 1024.18 g/mol
• CAS Number: 121062-08-6
• PubChem CID:92432
• Form: Lyophilized powder
• Storage: Store dry in a cool, dark environment (2°C to 8°C)

Research Context:
Melanotan II is commonly studied for its potential effects on:

• Melanocortin receptor (MC1R–MC5R) binding affinity and downstream signaling cascades
• Melanogenesis induction and eumelanin production in melanocyte models
• MC4R-mediated regulation of energy homeostasis and appetite signaling pathways
• Sexual function-related neuroendocrine pathways via hypothalamic melanocortin activation
• Photoprotective mechanisms and UV-induced DNA damage response in skin biology models
• Cyclic peptide structure-activity relationships in melanocortin receptor pharmacology

Intended Use:
This product is intended strictly for laboratory research applications only by qualified scientific personnel. It is not approved for human or animal consumption, and may not be used in foods, drugs, supplements, cosmetics, or diagnostics.

Legal Disclaimer:
The statements provided and this compound have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of any disease. Use is restricted to qualified researchers operating in certified laboratory environments.

Terms of Sale:
By purchasing this product, the buyer affirms they are a qualified researcher or institutional purchaser, fully responsible for proper handling, storage, and legal compliance.