Kisspetin-10

Overview

Kisspeptin-10 is a synthetic peptide representing an active fragment within the kisspeptin family, a group of signaling peptides studied for their role in the hypothalamic-pituitary-gonadal (HPG) axis and broader neuroendocrine regulation.

In laboratory and preclinical research environments, Kisspeptin-10 is investigated for its interaction with the KISS1 receptor (KISS1R) and its influence on pulsatile endocrine signaling, feedback mechanisms, and developmental pathway regulation. Its upstream signaling role makes it an important compound for studying coordinated neuroendocrine communication.

Jayasena C.N. et al., 2014

Development Background

Kisspeptin was first identified in 1996 during cancer biology research as a metastasis suppressor gene product, initially referred to as metastin. Its endocrine significance was recognized in the early 2000s when mutations involving the kisspeptin signaling pathway were linked to disrupted reproductive axis signaling in research models.

This discovery established kisspeptin peptides as key regulators of neuroendocrine function and led to extensive investigation into their role in hypothalamic signaling, developmental biology, and endocrine system dynamics.

Mills E.G. & Dhillo W.S., 2022

Molecular Profile

Compound Name: Kisspeptin-10 CAS Number: 374675-21-5 Molecular Formula: C₆₃H₈₃N₁₇O₁₄ Molecular Weight: 1302.45 g/mol PubChem ID: 25240297

Research Findings

Kisspeptin-10 has been extensively evaluated across neuroendocrine, hypothalamic, developmental, and receptor-signaling research models. Published findings describe its involvement in upstream endocrine regulation and coordinated signaling pathways.

Key Areas of Research

Neuroendocrine Systems Pulsatile signaling dynamics, endocrine cascade regulation, pathway coordination

Hypothalamic Research KNDy neuron systems, arcuate nucleus signaling, median eminence pathways

Receptor Pharmacology KISS1R activation, ligand signaling dynamics, pathway distribution

Developmental Biology Maturation signaling, axis establishment, endocrine pathway regulation

Collectively, these findings support Kisspeptin-10 as a specialized investigational compound for studying neuroendocrine integration, hypothalamic signaling networks, and endocrine developmental pathways in laboratory models.

Trevisan C.M. et al., Frontiers in Endocrinology, 2018

References

Jayasena C.N. et al. (2014). Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. Journal of Clinical Investigation, 124(8):3667–3677.

Mills E.G. & Dhillo W.S. (2022). Translating kisspeptin and neurokinin B biology into new therapies for reproductive health. Journal of Neuroendocrinology, 34(10):e13201.

Trevisan C.M. et al. (2018). Role of kisspeptin and neurokinin B in puberty in female non-human primates. Frontiers in Endocrinology, 9:148.