MOTS-C

MOTS-C – Premium Research Peptide

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-C) is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene. This 16-amino acid peptide has garnered significant research interest due to its unique mitochondrial origin and its observed effects on metabolic regulation and AMPK signaling in preclinical studies.

This product is intended for laboratory and research purposes only. Research Use Only.

Molecular Characteristics

Unlike most peptides which are encoded by nuclear DNA, MOTS-C is derived from a short open reading frame within the mitochondrial genome. This mitochondrial origin places MOTS-C in a novel class of signaling molecules that may represent communication between mitochondria and nuclear gene expression. The peptide sequence (MRWQEMGYIFYPRKLR) is highly conserved across species.

Research Applications

MOTS-C has been investigated in various research contexts including:

• Mitochondrial-nuclear crosstalk and retrograde signaling
• Metabolic homeostasis and AMPK-mediated pathway regulation
• AMPK pathway activation and cellular energy dynamics
• Mitochondrial signaling in skeletal tissue models
• Age-associated metabolic pathway changes in research models
• Cellular stress response mechanisms
• Substrate utilization and metabolic flux pathways

Published research suggests MOTS-C may translocate to the nucleus during metabolic stress and influence gene expression related to metabolic regulation, representing a novel paradigm in mitochondrial signaling research.

Technical Specifications

• Sequence: MRWQEMGYIFYPRKLR
• CAS Number: 1627580-64-6
• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₃S₂
• Molecular Weight: 2,174.64 g/mol
• Amino Acids: 16
• Purity: ?99%
• Form: Lyophilized powder
• Storage: Store at -20°C, protected from light